Victor Hanson-Smith

victor.hanson-smith at

Research Interests:
I develop new algorithms and software to study the evolution of genome architectures in Eukaryote species (i.e., animals, plants, and fungus). I use a wide range of computational approaches, including phylogenetics, high-throughput sequencing, data mining, and molecular dynamics. Additionally, I am a full-stack Django web developer on Amazon Web Services, with 15 years experience engineering in C/C++, Python, and Java. Depending on the day and the project, I am a scientist, software engineer, bioinformatician, and teacher.

Selected Publications:
Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ. Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. Elife. 2014 Oct 13;3. 

Yona AH, Bloom-Ackermann Z, Frumkin I, Hanson-Smith V, Charpak-Amikam Y, Feng Q, Boeke JD, Dahan O, Pilpel Y. tRNA genes rapidly change in evolution to meet novel translational demands. Elife. 2013 Dec20;2:e01339.

Baker CR, Hanson-Smith V, Johnson AD. Following gene duplication, paralog interference constrains transcriptional circuit evolution. Science. 2013 Oct4;342(6154):104-8.

Finnigan GC, Hanson-Smith V, Stevens TH, Thornton JW. Evolution of increased complexity in a molecular machine. Nature. 2012 Jan 9;481(7381):360-4.

Hanson-Smith V, Kolaczkowski B, Thornton JW. Robustness of ancestral sequence reconstruction to phylogenetic uncertainty. Mol Biol Evol. 2010 Sep;27(9):1988-99.