sheena.singh at ucsf.edu
I am interested in the transcription regulatory networks that govern pathogenesis in yeast. Specifically, I am dissecting the differences between pathogenic yeast and their non-pathogenic relatives in order to understand the evolutionary changes that ultimately gave rise to pathogenicity.
Singh-Babak SD, Shekhar T, Smith AM, Giaever G, Nislow C, Cowen LE. A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae. Mol Biosyst. 2012 Oct;8(10):2575-84.
Singh-Babak SD, Babak T, Diezmann S, Hill JA, Xie JL, Chen YL, Poutanen SM, Rennie RP, Heitman J, Cowen LE. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. PLoS Pathog. 2012;8(5):e1002718.
Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE. Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS Pathog. 2009 Jul;5(7):e100053